Georgia Institute of TechnologySchool of Chemical & Biomolecular Engineering
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Andreas Bommarius

Professor

Contact Information

Building: Petit IBB
Office: 3310
Phone: 404.385.1334
Fax: 404.894.2291
email

Mailing Address

Georgia Institute of Technology
School of Chemical &
Biomolecular Engineering
311 Ferst Drive, N.W.
Atlanta, GA 30332-0100

Links

Publications


Books

A.S. Bommarius and B.R. Riebel, “Biocatalysis – Fundamentals and Applications”, Wiley-VCH, 2004, ISBN: 3-527303-448
(Thank you to all our readers! We made the TopTen list of the most successful, non-textbook Wiley-VCH titles for 2004!)


Refereed Papers

  1. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, "Support Vector Machines for Predicting the Critical Positions of a Protein", J. Theor. Biol. 2005, 43, 000; web release January 25, 2005

  2. P.R. Gibbs, C.S. Uehara, U. Neunert, and A.S. Bommarius, "Accelerated biocatalyst stability testing for process optimization", Biotech. Progr. 2005, 21, 000; web release March 5, 2005

  3. G.T. Lountos, B.R. Riebel, W.B. Wellborn, A.S. Bommarius, A.M. Orville, "Crystallization and Preliminary Analysis of a Water-Forming NADH Oxidase from Lactobacillus sanfranciscensis", Acta Cryst. D, 2004, 60, 2044-47

  4. R. Jiang and A.S. Bommarius, "Hydrogen peroxide-producing NADH oxidase (nox 1) from Lactococcus lactis", Tetrah. Asymm. 2004, 15, 2939-44

  5. P. Ödman, W.B. Wellborn, A.S. Bommarius, "An enzymatic process to -ketoglutarate from L-glutamate: the coupled system L-glutamate dehydrogenase/NADH oxidase", Tetrah. Asymm. 2004, 15, 2933-37

  6. J. Lu, M.J. Lazzaroni, J.P. Hallett, A.S. Bommarius, C.L. Liotta, and C.A. Eckert, "Tunable Solutions for Homogeneous Catalyst Recycle", I&EC Research 2004, 43, 1586-1590

  7. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of both NAD+ from NADH and NADP+ from NADPH: NADH oxidase from Lactobacillus sanfranciscensis", Adv. Synth. Cat., 2003, 345, 707-712

  8. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of NAD+ from NADH: novel water-forming NADH oxidases", Advanced Synthesis and Catalysis, 2002, 344, 1156-1169

  9. O. May, S. Verseck, A.S. Bommarius, and K. Drauz, "Development of Dynamic Kinetic Resolution Processes for Biocatalytic Production of Natural and Nonnatural L-Amino Acids", Organic Process Research & Development. 2002, 6, 452-457

  10. J. Wöltinger, K. Drauz and A. S. Bommarius, "The Membrane Reactor in the Fine Chemicals Industry", Appl. Catalysis A: General. 2001, 221, 171–185

  11. S. Verseck, A.S. Bommarius and M.-R. Kula, "Screening, Overexpression and Characterization of an N-Acylamino Acid Racemase from Amycolatopsis orientalis subsp. lurida", Appl. Microbiol. Biotechnol. 2001, 55, 354-361

  12. A.S. Bommarius, M. Schwarm and K. Drauz, "Comparison of Different Chemoenzymatic Process Routes to Enantiomerically Pure Amino Acids", Chimia 2001, 55, 50-59

  13. J. Wöltinger, H. Henniges, A.S. Bommarius, H.-P. Krimmer and K. Drauz, "Application of the continuous Sharpless-dihydroxylation", Tetrahedron Asymmetry 2001, 12, 2095-2098

  14. J. Wöltinger, A.S. Bommarius, K. Drauz and C. Wandrey, "The Chemzyme Membrane Reactor in the Fine Chemicals Industry", Organic Process Research & Development, 2001, 5, 241-248

  15. A.S. Bommarius, K. Drauz, S. Eils, J. Kirchhoff and M. Schwarm, "Reduction Technologies in the Industrial Synthesis of Fine Chemicals", Chimica Oggi 2000, 18, 12-17

  16. A.S. Bommarius, M. Schwarm and K. Drauz, "Biocatalysis to Amino Acid-based Chiral Pharmaceuticals - Examples and Perspectives", J. Mol. Cat B: Enzymatic 1998, 5, 1-11

  17. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Synthesis of dipeptides by suspension-to-suspension conversion via thermolysin catalysis - from analytical to preparative scale", J. Peptide Science 1997, 3, 245-251

  18. G. Krix, A.S. Bommarius, K. Drauz, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Enzymatic reduction of a-keto acids leading to L-amino acids or D-hydroxy Acids", J. Biotechnology 1997, 53, 29-39;

  19. A.S. Bommarius, K. Drauz, K. Günther, G. Knaup and M. Schwarm, "L-Methionine Related L-Amino Acids by Acylase Cleavage of Their Corresponding N-Acetyl-DL-Derivatives", Tetrahedron Asymmetry 1997, 8, 3197-3200

  20. U. Stelkes-Ritter, G. Beckers, A.S. Bommarius, K. Drauz, K. Günther, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Kinetics of peptide amidase and its application for the resolution of racemates", Biocatalysis and Biotransformations 1997, 15, 205-219

  21. A.S. Bommarius, M. Schwarm and K. Drauz, "The membrane reactor for the acylase process - from laboratory results to commercial scale", Chimica Oggi 1996, 14(10), 61-64;

  22. A.S. Bommarius, D.I.C. Wang and T.A. Hatton, "Xanthine Oxidase Reactivity in Reversed Micellar Systems: A Contribution to the Prediction of Enzymatic Activity in Organized Media", J. Amer. Chem. Soc. 1995, 117, 4515-4523;

  23. U. Joeres, A.S. Bommarius, J. Thömmes & M.-R. Kula, "Studies on the kinetics and application of L-carnitine amidase for production of L-carnitine", Biocatalysis & Biotransformation 1995, 12, 27-36;

  24. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Environmentally acceptable synthesis of peptides in high yields by suspension-to-suspension conversion via protease catalysis", PEPTIDES 1994, (Hrsg.: H.L.S. Maia), Escom, Leiden, 1995, 226-7;

  25. T.A. Hatton and A.S. Bommarius, "A population balance analysis of substrate distribution effects on enzymatic reaction rates in reversed micelles", Proceedings of the Material Research Society 1995, 366, 439-444;

  26. A.S. Bommarius, M. Schwarm, K. Stingl, M. Kottenhahn, K. Huthmacher and K. Drauz, "Synthesis and Use of Enantiomerically Pure tert.-Leucine", Tetrahedron Asymmetry 1995, 6, 2851-2888;

  27. A. Fischer, A.S. Bommarius, K. Drauz and C. Wandrey, "A novel approach to enzymatic peptide synthesis using highly solubilizing Na-protecting groups of amino acids", Biocatalysis 1994, 8, 289-307;

  28. A.S. Bommarius, K. Drauz, W. Hummel, M.-R. Kula and C. Wandrey, "Some new developments in reductive amination with cofactor regeneration", Biocatalysis 1994, 10, 37-47;

  29. A.S. Bommarius and K. Drauz, "An Enzymatic Route to L-Ornithine from Arginine - Activation, Selectivity and Stabilization of L-Arginase", Bioorganic and Medicinal Chemistry 1994, 2, 617-626;

  30. C. Petit, A.S. Bommarius, M.-P. Pileni and T.A. Hatton, "Characterization of a Four-Component Cationic Reversed Micellar System: DTAC/Hexanol/n-Heptane/0.1 M KCl Solution", J. Phys.Chem. 1992, 96, 4653-58;

  31. A.S. Bommarius, K. Drauz, H. Klenk und C. Wandrey, "Operational Stability of Enzymes - Acylase-Catalyzed Resolution of N-Acetyl Amino Acids to Enantiomerically Pure L-Amino Acids", Annals N.Y. Acad. Sci. (Enzyme Eng. XI) 1992, 672, 126-36;

  32. A.S. Bommarius, M. Kottenhahn, H. Klenk and K. Drauz, "A versatile direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activity", in: "Microbial Reagents in Organic Synthesis", ed.: S. Servi, Kluwer Acad. Publ., Dordrecht, London, Boston, NATO ASI Series 1992, C 381, 161-174;

  33. E.B. Leodidis, A.S. Bommarius and T.A. Hatton, "Amino Acids in Reversed Micelles: Dependence of the Interfacial Partition Coefficient on Excess Phase Salinity and Interfacial Curvature", J. Phys. Chem. 1991, 95, 5943-56;

  34. A.S. Bommarius, K. Makryaleas & K. Drauz, "An Enzymatic Route to L-Ornithine from L-Arginine; Activation and Stabilization Studies on L-Arginase", Biomed. Biochim. Acta 1991, 50, 249-55

  35. A. Fischer, A. Schwarz, C. Wandrey, A.S. Bommarius, G. Knaup and K. Drauz, "Preparative-scale enzyme-catalyzed peptide synthesis using solubilizing N-terminal protecting groups", Biomed. Biochim. Acta 1991, 50, 169-74;

  36. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang & T.A. Hatton, "Coalescence and Solubilizate Exchange in a Cationic Four Component Reversed Micellar System", J. Phys. Chem. 1990, 94, 7232-39;

  37. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang and T.A. Hatton, "A Population Balance Model for the Determination of Solubilizate Exchange Rate Constants in Reversed Micellar Systems", in: "Structure, Dynamics, and Equilibrium Properties in Colloidal Systems", NATO ASI Series C 1990, 324, 181-99, eds.: H.B. Bloor & E. Wyn-Jones, Kluwer Acad. Publ., Dordrecht, London, Boston;

  38. J.W. Shield, H.D. Ferguson, A.S. Bommarius and T.A. Hatton, "Enzymes in Reversed Micelles as Catalysts for Organic-Phase Reactions"; Ind. Eng. Chem. Fundam. 1986, 25, 603-612;


Refereed Proceedings

A.S. Bommarius, M. Estler and K. Drauz, "Reaction engineering of large-scale enzymatic reductive amination processes", Proceedings for "INBIO 98", Amsterdam/NL, Feb. 19-20, 1998


Book Chapters

  1. A.S. Bommarius, "Hydrolysis of C-N bonds: acylases", in: "Handbook of Enzyme Catalysis in Organic Synthesis", eds.: K. Drauz and H. Waldmann, Wiley-VCH, Weinheim, 2002, 741-759

  2. D.R. Rozzell and A.S. Bommarius, "Transaminations", in: "Handbook of Enzyme Catalysis in Organic Synthesis", eds.: K. Drauz and H. Waldmann, Wiley-VCH, Weinheim, 2002, 873-89

  3. A.S. Bommarius, "Reduction of C=N-Bonds", in: "Handbook of Enzyme Catalysis in Organic Synthesis", eds.: K. Drauz and H. Waldmann, Wiley-VCH, Weinheim, 2002, 1047-1063

  4. U. Groeger and A.S. Bommarius, "Hydrolysis of N-Acyl Amino Acids", in: "Handbook of Enzyme Catalysis in Organic Synthesis", K. Drauz and H. Waldmann (eds.), VCH, Weinheim, Basel, Deerfield Beach, 1995, 393-408;

  5. A.S. Bommarius, "Reduction of C=N-Bonds", in: "Handbook of Enzyme Catalysis in Organic Synthesis", K. Drauz & H. Waldmann (eds.), VCH, Weinheim, Basel, Deerfield Beach, 1995, 633-641;

  6. A.S. Bommarius, "Biotransformations and Enzyme Reactors", in: Vol. 3 "Bioprocessing", Chapter 17, G.N. Stephanopoulos (ed.), in Series "Biotechnology", H.-J. Rehm and G. Reed (Series eds.), 2. ed., VCH, Weinheim, Basel, Deerfield Beach, 1993, 427-466;

  7. A.S. Bommarius, K. Drauz, U. Groeger and C. Wandrey, "Membrane Bioreactors for the Production of Enantiomerically Pure a-Amino Acids", in: "Chirality in Industry", eds.: A.N. Collins, G.N. Sheldrake and J. Crosby, Wiley & Sons Ltd., London, New York, 1992, Chapter 20, 371-397;


Patents (US Patents Only)

  1. J. Altenbuchner, R. Mattes, C. Syldatk, A. Wiese, B. Wilms, A.S. Bommarius, and W. Tischer, "Whole-cell catalysts", US 6,713,288, 2004; SI 87579, 2004

  2. S. Verseck, A.S. Bommarius, K. Drauz, and M.-R. Kula, "Acetyl amino acid racemase from Amycolatopsis orientalis for racemizing carbamoyl amino acids", US 6,767,725, 2004

  3. S. Laue, A. Liese, C. Wandrey, O. Burkhardt, J. Wöltinger, A.S. Bommarius, H. Henniges, J.-L. Philippe, A. Karau, K. Drauz, "Use of molecular weight-enlarged catalysts in a process for asymmetric continuous hydrogenation, novel molecular weight-enhanced ligands and catalysts", US 6,759,559, 2004

  4. M. Werner, J. Altenbuchner, R. Mattes, O. May, A.S. Bommarius, C. Syldatk , "Arthrobacter D-Carbamoylase and methods of preparing enantiomerically enriched D-amino acids", US 6,800,464 2004

  5. "Process for the production of amino acids using racemase and acylase", A.S. Bommarius, K. Drauz, and S. Verseck, US 6,656,710; 2003

  6. "Hydantoinase variants with improved properties and their use for the production of amino acids", F.H. Arnold, O. May, K. Drauz, and A.S. Bommarius, US 6,524,837; 2003

  7. "Molecular weight-enlarged ligands for asymmetric, homogeneously soluble hydrogenation catalysts, process for the production thereof and use", H.-P. Krimmer, J. Woeltinger, O. Burkhardt, I. Klement, H. Henniges, K. Drauz, A. Bommarius, J.-L. Philippe, and A. Karau, US 6,617,480; 2003

  8. "Polymeric diphosphine ligands for homogeneously soluble hydrogenation catalysts, process for their manufacture, and their use", O. Burkhardt, A.S. Bommarius, A. Karau, J. L. Philippe, J. Wöltinger, K. Drauz & G. Oehme, US 6,624,248; 2003

  9. "Process for the production of amino acids using racemase and acylase", A.S. Bommarius, K. Drauz, and S. Verseck,
    US 6,656,710; 2003

  10. "Hydantoinase variants with improved properties and their use for the production of amino acids", F.H. Arnold, O. May, K. Drauz, and A.S. Bommarius, US 6,524,837; 2003

  11. "Molecular weight-enlarged ligands for asymmetric, homogeneously soluble hydrogenation catalysts, process for the production thereof and use", H.-P. Krimmer, J. Woeltinger, O. Burkhardt, I. Klement, H. Henniges, K. Drauz, A. Bommarius, J.-L. Philippe, and A. Karau, US 6,617,480; 2003

  12. "Polymeric diphosphine ligands for homogeneously soluble hydrogenation catalysts, process for their manufacture, and their use; O. Burkhardt, A.S. Bommarius, A. Karau, J.-L. Philippe, J. Wöltinger, K. Drauz & G. Oehme, US 6,624,248; 2003

  13. "Process for the production of organic compounds in a membrane reactor", A. Karau, J. Wöltinger, O. Burkhardt, A.S. Bommarius, K. Boldt, J.-L. Philippe, H. Henniges and K. Drauz, US 6,472,571; 2002

  14. "L-Aminoacid Oxidase from Rhodococcus opacus", B. Geueke, W. Hummel and A.S. Bommarius, US 6,461,841; 2002

  15. "Process for obtaining microorganisms containing peptide amidases, microorganisms obtained therewith, peptide amidases contained therein, and their uses", M.-R. Kula, U. Stelkes-Ritter, K. Wyzgol, A.S. Bommarius, M. Schwarm and K. Drauz, US 6,333,176; 2002

  16. "N-Acetyl amino acid racemase", S. Verseck, A.S. Bommarius, K. Drauz and M.-R. Kula, US 6,372,459; 2002

  17. "Process for the oxidation of alcohols using homogeneously soluble polymer-enlarged nitrogen compounds as the catalyst", O. Burkhardt, J. Wöltinger, A. Karau, J.-L. Philippe, H. Henniges, A.S. Bommarius, H.-P. Krimmer and K. Drauz, US 6,451,943; 2002

  18. "Process for the catalytic, enantioselective reduction of ketones", C. Wandrey, U. Kragl, G. Giffels, M. Felder, C. Bolm, N. Derrien, A.S. Bommarius and K. Drauz, US 6,180,837; 2001

  19. "Process for the manufacture of MeO-PEG-protected dihydrochinone- or dihydrochinidine derivatives, new dihydrochinine- or dihydrochinidine derivatives as well as use thereof", A. Gerlach, A.S. Bommarius, K. Drauz and C. Bolm, US 6,180,551; 2001

  20. "New process for the manufacture of peptides and N-carbamoyl-protected peptides", A.S. Bommarius, K. Drauz, U. Eichhorn, H.-D. Jakubke and M. Kottenhahn, US 6,251,625; 2001

  21. "Process for the racemization of N-acetyl-D(L)-alpha-aminocarbonic acids", K. Drauz, A.S. Bommarius, M. Karrenbauer and G. Knaup, US 6,080,885; 2000

  22. "Process for optically active L-amino acids from corresponding racemic D(L)-alpha-aminocarbonic acids", K. Drauz, A.S. Bommarius, M. Karrenbauer and G. Knaup, US 6,114,163; 2000

  23. "Process for the production of microorganisms containing peptide amidases, the microorganisms produced, the peptide amidases contained therein, and their uses", M.-R. Kula, U. Stelkes-Ritter, K. Wyzgol, A.S. Bommarius, M. Schwarm and K. Drauz, US 5,985,623; 1999

  24. "New microorganisms, their use, and process for the manufacture of L-alpha-amino acids", F. Wagner, D. Völkel, A.S. Bommarius and K. Drauz, US 5,827,717; 1998

  25. US 5,304,470 "Process for the Enzymatic Synthesis of Protected Di- and Oligopeptides in Homogeneous, Highly
    1994 Concentrated, Aqueous Solution, A. Fischer, A. Schwarz, C. Wandrey, A.S. Bommarius, G. Knaup and K. Drauz

  26. US 5,369,018 Process for the manufacture of peptides and its use, 1994 H.-D. Jakubke, D. Ullmann, K. Drauz and A.S. Bommarius

  27. US 5,516,660 New microorganisms, their use, and process for the manufacture of L-alpha-amino acids, 1996 F. Wagner, D. Völkel, A.S. Bommarius and K. Drauz

  28. US 5,554,518 Stabilized, metal-ion activated L-arginase (L-Arginine Amidinohydrolase; E.C. 3.5.3.1.), 1996 A.S. Bommarius, K. Drauz, H. Klenk and K. Makryaleas

  29. US 5,608,076 Process for the manufacture of aminoalkylhydantoins for use as precursor of aminoalkylamino acids, 1997 M. Kottenhahn, A.S. Bommarius and K.Drauz

  30. US 5,591,613 Method for the preparation of D-arginine and L-ornithine, 1997 K. Makryaleas, K. Drauz and A.S. Bommarius

  31. US 5,670,332 Enzymatic process and corresponding apparatus for its use, 1997 P. Kuhl, U. Eichhorn, H.D. Jakubke, K. Drauz and A.S. Bommarius