Georgia Institute of TechnologySchool of Chemical & Biomolecular Engineering
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Andreas Bommarius

Professor

Contact Information

Building: Petit IBB
Office: 3310
Phone: 404.385.1334
Fax: 404.894.2291
email

Mailing Address

Georgia Institute of Technology
School of Chemical &
Biomolecular Engineering
311 Ferst Drive, N.W.
Atlanta, GA 30332-0100

Links

Publications


Books

A.S. Bommarius and B.R. Riebel, “Biocatalysis – Fundamentals and Applications”, Wiley-VCH, 2004, ISBN: 3-527303-448
(Thank you to all our readers! We made the TopTen list of the most successful, non-textbook Wiley-VCH titles for 2004!)


Refereed Papers

  1. J.F. Chaparro-Riggers, K.M. Polizzi, E. Vazquez-Figueroa, T.A. Rogers, and A.S. Bommarius, “Comparison of three Enoate Reductases and their potential use for biotransformations”, Adv. Synth. Catal. 2007, 349, 1521-1531

  2. E.M. Hill, J.M. Broering, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, “Coupling Chiral Homogeneous Biocatalysis with Benign Separation OATS for chiral hydrolyses”, Green Chemistry 2007, 9, 888-893

  3. K.M. Polizzi, D.A. Moore, and A.S. Bommarius, “A short-chain dehydrogenase/reductase from Vibrio vulnificus with both blue fluorescence and oxidoreductase activity”, Chem. Comm. 2007, 1843-5

  4. K.M. Polizzi, A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers, “Stability of enzymes”, Curr. Opin. Chem. Biol. 2007, 11, 220-225

  5. J.F. Chaparro-Riggers, K.M. Polizzi, A.S. Bommarius, “Better library design: data-driven protein engineering”, Biotechnol. J. 2007, 2, 180-191

  6. T.L. Thaler, P.R. Gibbs, R.P. Trebino, and A.S. Bommarius, “Search for Extraterrestrial Life Using Chiral Molecules: Mandelate Racemase as a Test Case”, Astrobiology 2006, 6, 910-920

  7. A.S. Bommarius, J.M. Broering, J.F. Chaparro-Riggers and K.M. Polizzi, “High-Throughput Screening for enhanced stability of proteins” , Curr. Opin. Biotechnology 2006, 18, 606-610

  8. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Identifying the Interacting Positions of a Protein using Boolean learning and Support Vector Machines”, Comp. Biol. Chem. 2006, 30, 268-279

  9. G.T. Lountos, R. Jiang, W.B. Wellborn, T.L. Thaler, A.S. Bommarius and A.M. Orville, “The Crystal Structure of NAD(P)H Oxidase from Lactobacillus sanfranciscensis: Insights into the Conversion of O2 into Two Water Molecules by the Flavoenzyme“, Biochemistry 2006, 45, 9648-9659

  10. K.M. Polizzi, M. Parikh, C.U. Spencer, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Pooling for Improved Screening of Combinatorial Libraries for Directed Evolution” , Biotechnol. Progr. 2006, 22, 961-967

  11. J.M. Broering, E.M. Hill, J.P. Hallett, C.L. Liotta, C.A. Eckert, and A.S. Bommarius, "Biocatalytic reaction and recycle using CO2-induced Organic Aqueous Tunable Solvents (OATS)", Angew. Chem. Intl. Ed. 2006, 45, 4670-4673

  12. K.M. Polizzi&, J.F. Chaparro-Riggers&, E. Vazquez-Figueroa, and A.S. Bommarius, “Structure-guided consensus approach to create a more thermostable penicillin G acylase”, Biotechnology J. 2006, 1, 531-536

  13. A.S. Bommarius and K.M. Polizzi, “Novel biocatalysts: recent developments”, Chem. Eng. Sci. 2006, 61, 1004-1016

  14. K.M. Polizzi, C.U. Spencer, A. Dubey, I. Matsumura, J.H. Lee, M.J. Realff, and A.S. Bommarius, “Simulation modeling of pooling for combinatorial protein engineering”, J. Biomol. Screening, 2005, 10, 856-864

  15. A.S. Bommarius and A. Karau, “Deactivation of formate dehydrogenase (FDH) in solution and at gas-liquid interfaces”, Biotechnol. Progr. 2005, 21, 1663-1672

  16. J.M. Broering and A.S. Bommarius, „Evaluation of Hofmeister effects on the kinetic stability of proteins“, J. Phys. Chem. B 2005, 109, 20612-19

  17. A.S. Bommarius and J.M. Broering, ““Established and novel tools to investigate biocatalyst stability”, Biocatalysis and Biotransformation 2005, 23, 125-139

  18. R. Jiang, B.R. Riebel and A.S. Bommarius, “Comparison of competing oxygen reduction pathways in Lactococcus lactis: four-electron vs. two-electron reduction by NADH oxidases”, Adv. Synth. Cat. 2005, 347, 1139-1146

  19. P.R. Gibbs, C.S. Uehara, U. Neunert, and A.S. Bommarius, “Accelerated biocatalyst stability testing for process optimization”, Biotech. Progr. 2005, 21, 762-774

  20. A. Dubey, M.J. Realff, J.H. Lee, and A.S. Bommarius, “Support Vector Machines for Predicting the Critical Positions of a Protein”, J. Theor. Biol. 2005, 234, 351-361

  21. G.T. Lountos, B.R. Riebel, W.B. Wellborn, A.S. Bommarius, A.M. Orville, "Crystallization and Preliminary Analysis of a Water-Forming NADH Oxidase from Lactobacillus sanfranciscensis", Acta Cryst. D, 2004, 60, 2044-47

  22. R. Jiang and A.S. Bommarius, "Hydrogen peroxide-producing NADH oxidase (nox 1) from Lactococcus lactis", Tetrah. Asymm. 2004, 15, 2939-44

  23. P. Ödman, W.B. Wellborn, A.S. Bommarius, "An enzymatic process to -ketoglutarate from L-glutamate: the coupled system L-glutamate dehydrogenase/NADH oxidase", Tetrah. Asymm. 2004, 15, 2933-37

  24. J. Lu, M.J. Lazzaroni, J.P. Hallett, A.S. Bommarius, C.L. Liotta, and C.A. Eckert, "Tunable Solutions for Homogeneous Catalyst Recycle", I&EC Research 2004, 43, 1586-1590

  25. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of both NAD+ from NADH and NADP+ from NADPH: NADH oxidase from Lactobacillus sanfranciscensis", Adv. Synth. Cat., 2003, 345, 707-712

  26. B.R. Riebel, P.R. Gibbs, W.B. Wellborn, and A.S. Bommarius, "Cofactor regeneration of NAD+ from NADH: novel water-forming NADH oxidases", Advanced Synthesis and Catalysis, 2002, 344, 1156-1169

  27. O. May, S. Verseck, A.S. Bommarius, and K. Drauz, "Development of Dynamic Kinetic Resolution Processes for Biocatalytic Production of Natural and Nonnatural L-Amino Acids", Organic Process Research & Development. 2002, 6, 452-457

  28. J. Wöltinger, K. Drauz and A. S. Bommarius, "The Membrane Reactor in the Fine Chemicals Industry", Appl. Catalysis A: General. 2001, 221, 171–185

  29. S. Verseck, A.S. Bommarius and M.-R. Kula, "Screening, Overexpression and Characterization of an N-Acylamino Acid Racemase from Amycolatopsis orientalis subsp. lurida", Appl. Microbiol. Biotechnol. 2001, 55, 354-361

  30. A.S. Bommarius, M. Schwarm and K. Drauz, "Comparison of Different Chemoenzymatic Process Routes to Enantiomerically Pure Amino Acids", Chimia 2001, 55, 50-59

  31. J. Wöltinger, H. Henniges, A.S. Bommarius, H.-P. Krimmer and K. Drauz, "Application of the continuous Sharpless-dihydroxylation", Tetrahedron Asymmetry 2001, 12, 2095-2098

  32. J. Wöltinger, A.S. Bommarius, K. Drauz and C. Wandrey, "The Chemzyme Membrane Reactor in the Fine Chemicals Industry", Organic Process Research & Development, 2001, 5, 241-248

  33. A.S. Bommarius, K. Drauz, S. Eils, J. Kirchhoff and M. Schwarm, "Reduction Technologies in the Industrial Synthesis of Fine Chemicals", Chimica Oggi 2000, 18, 12-17

  34. A.S. Bommarius, M. Schwarm and K. Drauz, "Biocatalysis to Amino Acid-based Chiral Pharmaceuticals - Examples and Perspectives", J. Mol. Cat B: Enzymatic 1998, 5, 1-11

  35. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Synthesis of dipeptides by suspension-to-suspension conversion via thermolysin catalysis - from analytical to preparative scale", J. Peptide Science 1997, 3, 245-251

  36. G. Krix, A.S. Bommarius, K. Drauz, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Enzymatic reduction of a-keto acids leading to L-amino acids or D-hydroxy Acids", J. Biotechnology 1997, 53, 29-39;

  37. A.S. Bommarius, K. Drauz, K. Günther, G. Knaup and M. Schwarm, "L-Methionine Related L-Amino Acids by Acylase Cleavage of Their Corresponding N-Acetyl-DL-Derivatives", Tetrahedron Asymmetry 1997, 8, 3197-3200

  38. U. Stelkes-Ritter, G. Beckers, A.S. Bommarius, K. Drauz, K. Günther, M. Kottenhahn, M. Schwarm and M.-R. Kula, "Kinetics of peptide amidase and its application for the resolution of racemates", Biocatalysis and Biotransformations 1997, 15, 205-219

  39. A.S. Bommarius, M. Schwarm and K. Drauz, "The membrane reactor for the acylase process - from laboratory results to commercial scale", Chimica Oggi 1996, 14(10), 61-64;

  40. A.S. Bommarius, D.I.C. Wang and T.A. Hatton, "Xanthine Oxidase Reactivity in Reversed Micellar Systems: A Contribution to the Prediction of Enzymatic Activity in Organized Media", J. Amer. Chem. Soc. 1995, 117, 4515-4523;

  41. U. Joeres, A.S. Bommarius, J. Thömmes & M.-R. Kula, "Studies on the kinetics and application of L-carnitine amidase for production of L-carnitine", Biocatalysis & Biotransformation 1995, 12, 27-36;

  42. U. Eichhorn, A.S. Bommarius, K. Drauz and H.-D. Jakubke, "Environmentally acceptable synthesis of peptides in high yields by suspension-to-suspension conversion via protease catalysis", PEPTIDES 1994, (Hrsg.: H.L.S. Maia), Escom, Leiden, 1995, 226-7;

  43. T.A. Hatton and A.S. Bommarius, "A population balance analysis of substrate distribution effects on enzymatic reaction rates in reversed micelles", Proceedings of the Material Research Society 1995, 366, 439-444;

  44. A.S. Bommarius, M. Schwarm, K. Stingl, M. Kottenhahn, K. Huthmacher and K. Drauz, "Synthesis and Use of Enantiomerically Pure tert.-Leucine", Tetrahedron Asymmetry 1995, 6, 2851-2888;

  45. A. Fischer, A.S. Bommarius, K. Drauz and C. Wandrey, "A novel approach to enzymatic peptide synthesis using highly solubilizing Na-protecting groups of amino acids", Biocatalysis 1994, 8, 289-307;

  46. A.S. Bommarius, K. Drauz, W. Hummel, M.-R. Kula and C. Wandrey, "Some new developments in reductive amination with cofactor regeneration", Biocatalysis 1994, 10, 37-47;

  47. A.S. Bommarius and K. Drauz, "An Enzymatic Route to L-Ornithine from Arginine - Activation, Selectivity and Stabilization of L-Arginase", Bioorganic and Medicinal Chemistry 1994, 2, 617-626;

  48. C. Petit, A.S. Bommarius, M.-P. Pileni and T.A. Hatton, "Characterization of a Four-Component Cationic Reversed Micellar System: DTAC/Hexanol/n-Heptane/0.1 M KCl Solution", J. Phys.Chem. 1992, 96, 4653-58;

  49. A.S. Bommarius, K. Drauz, H. Klenk und C. Wandrey, "Operational Stability of Enzymes - Acylase-Catalyzed Resolution of N-Acetyl Amino Acids to Enantiomerically Pure L-Amino Acids", Annals N.Y. Acad. Sci. (Enzyme Eng. XI) 1992, 672, 126-36;

  50. A.S. Bommarius, M. Kottenhahn, H. Klenk and K. Drauz, "A versatile direct route from hydantoins to D-amino acids employing a resting cell biocatalyst with D-hydantoinase and D-carbamoylase activity", in: "Microbial Reagents in Organic Synthesis", ed.: S. Servi, Kluwer Acad. Publ., Dordrecht, London, Boston, NATO ASI Series 1992, C 381, 161-174;

  51. E.B. Leodidis, A.S. Bommarius and T.A. Hatton, "Amino Acids in Reversed Micelles: Dependence of the Interfacial Partition Coefficient on Excess Phase Salinity and Interfacial Curvature", J. Phys. Chem. 1991, 95, 5943-56;

  52. A.S. Bommarius, K. Makryaleas & K. Drauz, "An Enzymatic Route to L-Ornithine from L-Arginine; Activation and Stabilization Studies on L-Arginase", Biomed. Biochim. Acta 1991, 50, 249-55

  53. A. Fischer, A. Schwarz, C. Wandrey, A.S. Bommarius, G. Knaup and K. Drauz, "Preparative-scale enzyme-catalyzed peptide synthesis using solubilizing N-terminal protecting groups", Biomed. Biochim. Acta 1991, 50, 169-74;

  54. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang & T.A. Hatton, "Coalescence and Solubilizate Exchange in a Cationic Four Component Reversed Micellar System", J. Phys. Chem. 1990, 94, 7232-39;

  55. A.S. Bommarius, J.F. Holzwarth, D.I.C. Wang and T.A. Hatton, "A Population Balance Model for the Determination of Solubilizate Exchange Rate Constants in Reversed Micellar Systems", in: "Structure, Dynamics, and Equilibrium Properties in Colloidal Systems", NATO ASI Series C 1990, 324, 181-99, eds.: H.B. Bloor & E. Wyn-Jones, Kluwer Acad. Publ., Dordrecht, London, Boston;

  56. J.W. Shield, H.D. Ferguson, A.S. Bommarius and T.A. Hatton, "Enzymes in Reversed Micelles as Catalysts for Organic-Phase Reactions"; Ind. Eng. Chem. Fundam. 1986, 25, 603-612;